The publication “Boosting advanced material’s innovation – Are we regulatory prepared?” (DOI: 10.1016/j.impact.2025.100576) explores how AdMa—ranging from nanomaterials to broader categories—intersect with chemical safety legislation, highlighting the need for clear legal definitions, robust methodologies, and regulatory preparedness. By addressing these challenges, policymakers, researchers, and innovators can ensure that advanced materials not only accelerate technological progress but also operate within a framework of legal clarity and safety, paving the way for Europe’s sustainable future.